This article will explain how you can disable the email auto responder on your VPS running Plesk 10
Login to your Parallels Plesk Panel.
Click on the Domains link on the left panel.
Click on then Control Panel link next to the relevant domain name.
Click on then Mail tab.
Click on the relevant email address that you would like to disable the auto responder for.
Click on the Auto-Reply tab.
Deselect the tick box next to the Switch on auto-reply option.
Click on the OK button.
Your Auto responder will now be switched off.